Endocrine Abstracts

Introduction and aim: Osteopetrosis is a rare genetic disorder of reduced osteoclastic bone resorption. Defective bone remodelling induces skeletal sclerosis and abnormally dense but brittle bones. We present here a case of autosomal dominant osteopetrosis type II as a cause of high bone mineral density (BMD).Case report: A 52-years-old woman with a complaint of bone pain and headache referred to our clinic for evaluation of high BMD. Her medical history...

Objective: Elevated levels of the soluble adhesion molecules, sICAM-1 and sVCAM-1 reflect chronic inflammatory state. Increased levels of sICAM-1 and sVCAM-1 were demonstrated in various autoimmune thyroid diseases with abnormal thyroid function, but their clinical significance is undefined, especially in the euthyroid patients with Hashimoto’s thyroiditis (HT). Increased levels of soluble adhesion molecules are also associated with components of the metabolic syndrome li...

Introduction: Primary hyperparathyroidism (PHPT) occurs a peak incidence between ages 50 and 60 and the classical bone disease of PHPT or pathological fractures due to PHPT is rarely seen today. Furthermore brown tumor detected with Tc-99m MIBI scintigraphy exists in literature infrequently.Case: A 23 years old woman presented with left arm pain admitted in Department of Orthopaedics for pathological fracture in left humerus. As a result of investigation...

Introduction: Thyrotropin secreting pituitary adenomas are rare constituting <2% of pituitary adenomas. Thirty percent of these tumors may be plurihormonal. Most common cosecreted hormone is GH and the least one is PRL. We report here a case of plurihormonal pituitary adenoma symptomatic for TSH secretion.Case report: A 35-year-old female admitted to hospital because of fatigue, heat intolerance, headache, galactorrhea and menstrual irregularity. Her...

Thyroidectomy is the definitive treatment for toxic multinodular goiter (TXMNG). Surgery should be performed when the patient is euthyroid which decreases perioperative cardiac risks. Plasmapheresis is a procedure that removes the thyroid hormones from the circulation. It is an alternative method in case of resistance or contraindications to anti thyroid drugs. Role of plasmapheresis in the treatment of TXMNG is not fully determined in the literature. We report a case with TXM...

Introduction: Sertoli–Leydig cell tumours are rare tumours which account for <1% of all solid ovarian tumors. It mostly occurs in 2–4° decades of life. Rapidly progessing symptoms/signs of androgen excess suggest the presence of and androgen secreting tumor.Case: Two postmenopausal patients (50 and 57 year-old) were referred to our Endocrinology Clinic for evaluation of worsening hirsutism. Both of patients had manifestations of hypera...

Objective: To compare the roles of inferior thyroid artery (ITA) peak systolic and end-diastolic velocities (PSV and EDV) measured by color flow Doppler ultrasonography (CFDUSG), TSH receptor antibody (TRAb) measured by M22 based ELISA and Tc-99m pertechnetate uptake for differential diagnosis between Graves’ disease (GD) and silent thyroiditis (ST).Methods: One hundred and fifty previously untreated subjects with GD (111 female, 39 male, mean age 3...

Background: Currently, there is no satisfying treatment option other than gross total or subtotal resection in combination with adjuvant radiotherapy for the treatment of craniopharyngiomas. However, recurrence could occur in a substantial proportion of craniopharyngiomas despite gross total resection and radiotherapy. Human epidermal growth factor receptor 2 (HER-2/ErbB2) overexpression was determined in various human carcinomas and is associated with aggressive clinical beha...

Introduction: The treatment of choice in Cushing’s disease (CD) is transsphenoidal adenomectomy. However, the long term recurrence rate of the CD after transsphenoidal surgery in Turkish patients has not been determined so far.Purpose: We aimed to determine the long term recurrence rates of CD in Turkish patients after transsphenoidal surgery.Methods: The computer records of the 23 patients, operated for CD in our center durin...

Introduction: The differential diagnosis between Graves’ disease (GD) and gestational transient thyrotoxicosis (GTT) is difficult in the absence of history and clinical features of GD. In this study, we aimed to determine the role of peak systolic (PSV) and end-diastolic velocities (EDV) of the right and left inferior thyroid arteries (ITA) as measured by color-flow Doppler ultrasonography (CFDUSG) for discriminating GTT from treatment naive GD.Meth...